Denosyl is a daily supplement that helps support proper liver function. Support of a compromised liver, regardless of the cause, is essential if function is to be improved. Denosyl has not only been shown to markedly increase glutathione levels in the livers of dogs and cats, but to go far beyond that. Denosyl has been shown to protect liver cells from cell death and may be useful in cell repair and healing. Its main ingredient is S-Adenosylmethionine (SAMe).
Because the tablet must be kept intact to prevent destruction by stomach acid, administration range is based on
the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may
also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of
For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the
presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty
administering tablets to their pets, Denosyl® tablet(s) may be disguised in a small bite of food. Studies
have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in
cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water
immediately following any tablet administration to speed passage of the tablet into the stomach.12,13 Denosyl 90
mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the
total number of tablets may be divided between morning and evening for ease of administration. For example, a
daily administration of three tablets could be divided into two tablets in the morning and one tablet in the
FELINE AND CANINE DENOSYL DAILY* ADMINISTRATION GUIDEFor Cats and Small Dogs
For Medium Dogs
|Body Weight||90mg Denosyl|
|Up to 12 lbs (up to 5.5 kg)||1 tablet|
For Large Dogs
|Body Weight||225mg Denosyl|
|13-34 lbs(6 to 15.5kg) ||1 tablet|
|Body Weight||425mg Denosyl|
|35-65 lbs (16-29.5 kg)||1 tablet|
|66-120 lbs (30-54.5 kg)||2 tablets|
|Over 120 lbs (Over 120 lbs)||3 tablets|
This product is for veterinary use in dogs and cats only.
*The number of tablets can be gradually reduced or increased at any time depending on the pet’s needs. Many
pets are maintained long-term on every-other-day or every-third-day administration.
Store in a cool dry place not to exceed 86° F.
Keep tablets in original blister pack until used.
Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.