Securely Order and Affordably Fill your Prescriptions Online, VIPPS Accredited & Licensed in all 50 States, Thousands of Medications Below Your Co-Pay or Deductible, No Insurance? No Problem! We Fill Cash Prescriptionslearn more
Browse Products from A to Z:

Processing time for OTC products remains 1-3 business days. Currently we're experiencing a surge in prescription medication order volume and are temporarily adding 2-4 extra days to normal prescription processing times. As always, we will try to ship your order as quickly as possible.

    Unfortunately our full catalog may not be displayed in your state. If you contact our Customer Support by one of the methods below, we will be able to assist you in locating the product you are looking for.

    Customer Support

    Phone: 1-800-748-7001


    We need just a little extra information

    As a VIPPS accredited pharmacy licensed in all 50 states, pharmacy regulation requires us to ask for your shipping zip code.

    Advantage II (For Extra Large Dogs, Over 55 lbs) - 4 Pack (Blue)

    Advantage II  (For Extra Large Dogs, Over 55 lbs) - 4 Pack (Blue)
    Download Mail In Order Form

    Product ID: 607056

    Price : Select Quantity Below

    In Stock
    - Select Quantity (Tubes) -
    1 Tube
    2 Tubes
    3 Tubes
    $163.90(Save 1%)
    Custom Tube Quantity
    Add To My Cart

    Product Summary

    • Kills all flea life stages within 12 hours of initial application
    • Stops biting fleas in 3-5 minutes
    • Kills reinfesting fleas within 2 hours
    • Works through contact, so fleas don’t have to bite to die
    • Kills lice
    • Waterproof


    For the Prevention and Treatment of Flea and Lice Infestations on Dogs

    Active Ingredients:

    Imidacloprid (9.1% by weight) and Pyriproxyfen (0.46% by weight)


    HAZARDS TO HUMANS: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. Wash hands thoroughly with soap and warm water after handling.

    HAZARDS TO DOMESTIC ANIMALS: For external use only. Do not use on puppies under 7 weeks of age. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing animals. Individual sensitivities, while rare, may occur after using ANY pesticide product for pets. If signs persist, or become more severe, consult a veterinarian immediately. If your animal is on medication, consult your veterinarian before using this or any other product.


    It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.


    1. Being careful not to cut close to the blister cavities, take scissors and cut off one section of the card containing a single tube.

    2. Take the separated section, and cut into the blister cavity across the small side, close to the cap of the tube.

    3. Peel off the foil, and take out the tube.

    4. Repeat steps 1 to 3 for each tube.


    1. Use only on dogs. Do not use on other animals.

    2. Remove one applicator tube from the package. See “HOW TO OPEN” section.

    3. Hold applicator tube in an upright position. Pull cap off tube.

    4. Turn the cap around and place other end of cap back on tube.

    5. Twist cap to break seal, then remove cap from tube.

    6. Application method depending on weight:

    - For dogs up to 20 lbs.: The dog should be standing for easy application. Part the hair on the dog’s back, between the shoulder blades, until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. Do not get this product in your pet’s eyes or mouth.

    - For dogs over 20 lbs.: The dog should be standing for easy application. Apply the entire contents of the tube evenly to three or four spots on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your pet’s eyes or mouth.

    7. Discard empty tube as described in Storage and Disposal.

    8. Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days. After flea control is obtained, return to a monthly retreatment schedule.

    Additional Information:,/h4>

    The successive feeding activity of fleas on dogs frequently elicits a hypersensitivity skin disorder known as flea allergy dermatitis (FAD) or flea bite hypersensitivity. Treatment of dogs with Advantage II rapidly kills fleas and reduces the incidence of this condition.

    Advantage II kills existing fleas on dogs within 12 hours. Reinfesting fleas are killed within 2 hours with protection against further flea infestation lasting for four (4) weeks. Pre-existing pupae in the environment may continue to emerge for six (6) weeks or longer depending upon the climatic conditions.

    Fleas, flea eggs, and flea larvae in the dog’s environment are killed following contact with an Advantage II treated pet. Advantage II provides multi-stage flea control effectively breaking all flea life-cycle stages for quick and lasting control of flea populations.

    Advantage II kills adult fleas quickly (within 12 hours), inhibits the development of immature flea life stages and prevents them from reaching the biting adult stage.

    Advantage II kills chewing lice that infest dogs and puppies, and prevents further infestations.

    Advantage II is waterproof and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight.

    Monthly treatments are required for optimal control and prevention of fleas.

    Storage and Disposal:

    Do not contaminate water, food or feed by storage or disposal.

    Pesticide Storage: Store in a cool, dry place.

    Pesticide Disposal and Container Handling: Nonrefillable container.

    If empty: Do not reuse or refill this container. Place in trash or offer for recycling if available.

    If partly filled: Call your local solid waste agency or 1-800-422-9874 for disposal instructions. Never place unused product down any indoor or outdoor drain

    Compare Prices

    Ratings And Reviews

    There are currently no reviews for this product. Be the first to review this product

    Happy Customers
    • Patrick M Z.  Momence, IL.

      “Very fast, good price, quality service !!”

    • Altha B. 

      “Health Warehouse has always been very professional and the customer service is excellent. The prices are excellent as well, I trust Health Warehouse to complete my orders and ship as promised. I will and do recommend them t...”

    • Melvin W.  Coshocton, OH.

      “Your service is great and the prices are fantastic!”

    • More Happy Customers


    1-888-870-2808 is a VIPPS accredited pharmacy based in Florence, Kentucky. Licensed to sell prescriptions in all 50 states and the District of Columbia, has become America’s Trusted Online Pharmacy for more than 7 years. For more information about how we’re revolutionizing pharmacy, one prescription at a time, click here.