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Denamarin for Large Dogs(35 lbs & Over)425mg - 30 Tablet Box(Purple)
Product ID: 607057
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Product Summary
  • The #1 veterinarian recommended liver support brand.*
  • Two active ingredients, one patented formula
  • A supplement for dogs and cats containing S-Adenosylmethionine (SAMe) and silybin


Denamarin, a patented nutritional supplement for veterinary use, combines a pure and stabilized S-Adenosylmethionine with silybin-phosphatidylcholine complex.

The combination of S-Adenosylmethionine and silybin in Denamarin provides a multi-faceted approach to liver support.

Silybin is the most biologically active component of an extract from milk thistle known as silymarin, and its absorption is enhanced by phosphatidylcholine. Silybin/silymarin has been shown to have beneficial effects on liver function.,/p>

S-Adenosylmethionine has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects hepatic cells from toxins and death. A study found that low liver glutathione concentrations are common in dogs and cats with decreased hepatobiliary function. Denamarin is recommended to improve hepatic glutathione levels in patients to help maintain and protect liver function. Denamarin may also be used in other areas of tissue oxidant injury and RBC fragility caused by certain toxins or drugs which are related to reduced glutathione concentrations. Denamarin’s mechanism of action, however, goes beyond increasing glutathione levels, in that S-Adenosylmethionine has also been shown to protect liver cells from cell death and may be useful in cell regeneration. A study has also shown that S-Adenosylmethionine may improve bile flow in cats.


For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine

For those owners who have difficulty administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in cats but may become lodged in the esophagus.

It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.

Denamarin for Cats and Small Dogs tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denamarin can be used in conjunction with Marin®to provide additional silybin levels and the benefits of vitamin E and zinc supplementation. If Marin is used in conjunction with Denamarin, the two products should be administered 12 hours apart for best response.

Denamarin For Cats and Small Dogs
Contains 90mg of S-Adenosylmethionine and 9 mg of silybin A+B
Body Weight Number of Tablets Per Day
Up to 12 lbs (5.5 kg) 1 tablet

Denamarin For Medium Dogs
Contains 225 mg of S-Adenosylmethionine and 24 mg of silybin A+B
Body Weight Number of Tablets Per Day
13-34 lbs (6-15.5 lbs) 1 tablet

Denamarin For Large Dogs
Contains 425 mg of S-Adenosylmethionine and 35 mg of silybin A+B
Body Weight Number of Tablets Per Day
35-65 lbs (16-29.5 kg) 1 tablet
66-120 lbs (30-54.5 kg) 2 tablets
Over 120 lbs (Over 120 lbs) 3 tablets


This product is for veterinary use in dogs and cats only.

Denamarin has no known serious side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, watch for improvements in your pet’s attitude, appetite, and activity level.

In the event of overdose: Contact your veterinarian or veterinary emergency room.


Store in a cool dry place not to exceed 86° F.

Keep tablets in original blister pack until used.

Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.

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