Denamarin, a patented nutritional supplement for veterinary use, combines a pure and stabilized S-Adenosylmethionine with silybin-phosphatidylcholine complex.
The combination of S-Adenosylmethionine and silybin in Denamarin provides a multi-faceted approach to liver support.
Silybin is the most biologically active component of an extract from milk thistle known as silymarin, and its absorption is enhanced by phosphatidylcholine. Silybin/silymarin has been shown to have beneficial effects on liver function.,/p>
S-Adenosylmethionine has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects hepatic cells from toxins and death. A study found that low liver glutathione concentrations are common in dogs and cats with decreased hepatobiliary function. Denamarin is recommended to improve hepatic glutathione levels in patients to help maintain and protect liver function. Denamarin may also be used in other areas of tissue oxidant injury and RBC fragility caused by certain toxins or drugs which are related to reduced glutathione concentrations. Denamarin’s mechanism of action, however, goes beyond increasing glutathione levels, in that S-Adenosylmethionine has also been shown to protect liver cells from cell death and may be useful in cell regeneration. A study has also shown that S-Adenosylmethionine may improve bile flow in cats.
For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine
For optimal absorption, the tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. Denamarin can be used in conjunction with Marin® for Dogs to provide additional silybin levels and the benefits of vitamin E and zinc supplementation. If Marin is used in conjunction with Denamarin the two products should be administered 12 hours apart for best response. .
The number of chewable tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian.
|Body Weight||Number of Tablets Per Day|
|Up to 6 lbs||1/4 tablet|
|7 to 15 lbs||1/2 tablet|
|16 to 30 lbs||1 tablet|
|31 to 45 lbs||1 1/2 tablets||45 to 60 lbs||2 tablets||61 to 75 lbs||2 1/2 tablets||76 to 90 lbs||3 tablets||91 to 105 lbs||3 1/2 tablets||over 105 lbs||4 tablets|
This product is for veterinary use in dogs only.
Denamarin has no known serious side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, watch for improvements in your pet’s attitude, appetite, and activity level.
In the event of overdose: Contact your veterinarian or veterinary emergency room.
Store in a cool dry place not to exceed 86° F. Keep bottle closed with desiccant inside when not removing tablets. Tablets are sensitive to moisture and extreme heat.
Keep lid tightly secured to ensure freshness.
Keep bottle out of the reach of children
This bottle contains one (1) non-toxic desiccant to help preserve freshness and ensure the shelf life of the product.